Definition of a critical spatiotemporal window within which primary cilia control midbrain dopaminergic neurogenesis

Midbrain dopaminergic (mDA) neurons are generated in the ventral midbrain floor plate depending on Sonic Hedgehog (SHH) signaling for induction. Primary cilia transduce canonical SHH signals. Loss of intraflagellar transport protein IFT88, essential for ciliary function, disrupts SHH signaling in th...

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Vydáno v:Neurogenesis (Austin)
Hlavní autoři: Gazea, Mary, Tasouri, Evangelia, Heigl, Tobias, Bosch, Viktoria, Tucker, Kerry L., Blaess, Sandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Brief Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129902/
https://ncbi.nlm.nih.gov/pubmed/28090543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23262133.2016.1248206
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