Definition of a critical spatiotemporal window within which primary cilia control midbrain dopaminergic neurogenesis

Midbrain dopaminergic (mDA) neurons are generated in the ventral midbrain floor plate depending on Sonic Hedgehog (SHH) signaling for induction. Primary cilia transduce canonical SHH signals. Loss of intraflagellar transport protein IFT88, essential for ciliary function, disrupts SHH signaling in th...

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Bibliografische gegevens
Gepubliceerd in:Neurogenesis (Austin)
Hoofdauteurs: Gazea, Mary, Tasouri, Evangelia, Heigl, Tobias, Bosch, Viktoria, Tucker, Kerry L., Blaess, Sandra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2016
Onderwerpen:
Brief Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129902/
https://ncbi.nlm.nih.gov/pubmed/28090543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23262133.2016.1248206
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