Definition of a critical spatiotemporal window within which primary cilia control midbrain dopaminergic neurogenesis

Midbrain dopaminergic (mDA) neurons are generated in the ventral midbrain floor plate depending on Sonic Hedgehog (SHH) signaling for induction. Primary cilia transduce canonical SHH signals. Loss of intraflagellar transport protein IFT88, essential for ciliary function, disrupts SHH signaling in th...

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Dades bibliogràfiques
Publicat a:Neurogenesis (Austin)
Autors principals: Gazea, Mary, Tasouri, Evangelia, Heigl, Tobias, Bosch, Viktoria, Tucker, Kerry L., Blaess, Sandra
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Brief Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129902/
https://ncbi.nlm.nih.gov/pubmed/28090543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23262133.2016.1248206
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