Active vacuolar H(+) ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P(2) loss under PIKfyve or Vps34 deficiency

Ítems similars

• Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation
  per: Shisheva, Assia, et al.
  Publicat: (2014)
• Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P(2) by means of the PIKfyve inhibitor YM201636
  per: Sbrissa, Diego, et al.
  Publicat: (2012)
• Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P(2) but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation
  per: Sbrissa, Diego, et al.
  Publicat: (2018)
• YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P(2) synthesis, halts glucose entry by insulin in adipocytes
  per: Ikonomov, Ognian C., et al.
  Publicat: (2009)
• Class III PI 3-Kinase is the Main Source of PtdIns3P Substrate and Membrane Recruitment Signal for PIKfyve Constitutive Function in Podocyte Endomembrane Homeostasis
  per: Ikonomov, Ognian C., et al.
  Publicat: (2015)