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Active vacuolar H(+) ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P(2) loss under PIKfyve or Vps34 deficiency
The two evolutionarily conserved mammalian lipid kinases Vps34 and PIKfyve are involved in an important physiological relationship, whereby the former produces phosphatidylinositol (PtdIns) 3P that is used as a substrate for PtdIns(3,5)P(2) synthesis by the latter. Reduced production of PtdIns(3,5)P...
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| Publicado no: | Am J Physiol Cell Physiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5129759/ https://ncbi.nlm.nih.gov/pubmed/27335171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00104.2016 |
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