Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel of CRC organoids carrying either wild-type or mutant RAS, as well as normal organoids and tumor organoids with a CRISPR-introduced oncogenic...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, van Gerwen, Bastiaan, van der Ven, Marieke, van de Wetering, Marc, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Cancer Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127645/
https://ncbi.nlm.nih.gov/pubmed/27845624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18489
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