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Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel of CRC organoids carrying either wild-type or mutant RAS, as well as normal organoids and tumor organoids with a CRISPR-introduced oncogenic...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, van Gerwen, Bastiaan, van der Ven, Marieke, van de Wetering, Marc, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Cancer Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127645/
https://ncbi.nlm.nih.gov/pubmed/27845624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18489
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