Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification

Knowledge of influenza virus evolution at the point of transmission and at the intrahost level remains limited, particularly for human hosts. Here, we analyze a unique viral data set of next-generation sequencing (NGS) samples generated from a human influenza challenge study wherein 17 healthy subje...

詳細記述

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書誌詳細
出版年:J Virol
主要な著者: Sobel Leonard, Ashley, McClain, Micah T., Smith, Gavin J. D., Wentworth, David E., Halpin, Rebecca A., Lin, Xudong, Ransier, Amy, Stockwell, Timothy B., Das, Suman R., Gilbert, Anthony S., Lambkin-Williams, Robert, Ginsburg, Geoffrey S., Woods, Christopher W., Koelle, Katia
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2016
主題:
Genetic Diversity and Evolution
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126380/
https://ncbi.nlm.nih.gov/pubmed/27707932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01657-16
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