Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification

Knowledge of influenza virus evolution at the point of transmission and at the intrahost level remains limited, particularly for human hosts. Here, we analyze a unique viral data set of next-generation sequencing (NGS) samples generated from a human influenza challenge study wherein 17 healthy subje...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Sobel Leonard, Ashley, McClain, Micah T., Smith, Gavin J. D., Wentworth, David E., Halpin, Rebecca A., Lin, Xudong, Ransier, Amy, Stockwell, Timothy B., Das, Suman R., Gilbert, Anthony S., Lambkin-Williams, Robert, Ginsburg, Geoffrey S., Woods, Christopher W., Koelle, Katia
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Genetic Diversity and Evolution
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126380/
https://ncbi.nlm.nih.gov/pubmed/27707932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01657-16
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