Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification

Knowledge of influenza virus evolution at the point of transmission and at the intrahost level remains limited, particularly for human hosts. Here, we analyze a unique viral data set of next-generation sequencing (NGS) samples generated from a human influenza challenge study wherein 17 healthy subje...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Sobel Leonard, Ashley, McClain, Micah T., Smith, Gavin J. D., Wentworth, David E., Halpin, Rebecca A., Lin, Xudong, Ransier, Amy, Stockwell, Timothy B., Das, Suman R., Gilbert, Anthony S., Lambkin-Williams, Robert, Ginsburg, Geoffrey S., Woods, Christopher W., Koelle, Katia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2016
Onderwerpen:
Genetic Diversity and Evolution
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126380/
https://ncbi.nlm.nih.gov/pubmed/27707932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01657-16
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