Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification

Knowledge of influenza virus evolution at the point of transmission and at the intrahost level remains limited, particularly for human hosts. Here, we analyze a unique viral data set of next-generation sequencing (NGS) samples generated from a human influenza challenge study wherein 17 healthy subje...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Sobel Leonard, Ashley, McClain, Micah T., Smith, Gavin J. D., Wentworth, David E., Halpin, Rebecca A., Lin, Xudong, Ransier, Amy, Stockwell, Timothy B., Das, Suman R., Gilbert, Anthony S., Lambkin-Williams, Robert, Ginsburg, Geoffrey S., Woods, Christopher W., Koelle, Katia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126380/
https://ncbi.nlm.nih.gov/pubmed/27707932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01657-16
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