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Fluorescence‐ and bioluminescence‐based approaches to study GPCR ligand binding

Ligand binding is a vital component of any pharmacologist's toolbox and allows the detailed investigation of how a molecule binds to its receptor. These studies enable the experimental determination of binding affinity of labelled and unlabelled compounds through kinetic, saturation (K(d)) and...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Stoddart, Leigh A, White, Carl W, Nguyen, Kim, Hill, Stephen J, Pfleger, Kevin D G
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125978/
https://ncbi.nlm.nih.gov/pubmed/26317175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13316
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