Structural basis for activity regulation of MLL family methyltransferases

The mixed lineage leukaemia (MLL) family of proteins (including MLL1–MLL4, SET1A and SET1B) specifically methylate histone 3 Lys4, and have pivotal roles in the transcriptional regulation of genes involved in haematopoiesis and development. The methyltransferase activity of MLL1, by itself severely...

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Veröffentlicht in:Nature
Hauptverfasser: Li, Yanjing, Han, Jianming, Zhang, Yuebin, Cao, Fang, Liu, Zhijun, Li, Shuai, Wu, Jian, Hu, Chunyi, Wang, Yan, Shuai, Jin, Chen, Juan, Cao, Liaoran, Li, Dangsheng, Shi, Pan, Tian, Changlin, Zhang, Jian, Dou, Yali, Li, Guohui, Chen, Yong, Lei, Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125619/
https://ncbi.nlm.nih.gov/pubmed/26886794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16952
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