Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude

Zebrafish larvae (Danio rerio) are increasingly used to translate findings regarding drug efficacy and safety from in vitro-based assays to vertebrate species, including humans. However, the limited understanding of drug exposure in this species hampers its implementation in translational research....

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Publicado en:Zebrafish
Autores principales: Kantae, Vasudev, Krekels, Elke H.J., Ordas, Anita, González, Oskar, van Wijk, Rob C., Harms, Amy C., Racz, Peter I., van der Graaf, Piet H., Spaink, Herman P., Hankemeier, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124745/
https://ncbi.nlm.nih.gov/pubmed/27632065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/zeb.2016.1313
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