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Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae

Zebrafish larvae are increasingly used in pharmacological and toxicological studies, but it is often overlooked that internal exposure to exogenous compounds, rather than the incubation medium concentration, is driving observed effects. Moreover, as the zebrafish larva is a developing organism, cont...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: van Wijk, Rob C., Krekels, Elke H. J., Kantae, Vasudev, Harms, Amy C., Hankemeier, Thomas, van der Graaf, Piet H., Spaink, Herman P.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377609/
https://ncbi.nlm.nih.gov/pubmed/30770889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38530-w
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