Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Hypertrophic differentiation occurs during in vitro chondrogenesis of mesenchymal stem cells (MSCs), decreasing the quality of the cartilage construct. Previously we identified WNT pathway antagonists Dickkopf 1 homolog (DKK1) and frizzled-related protein (FRZB) as key factors in blocking hypertroph...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Stem Cells Dev
Egile Nagusiak: Zhong, Leilei, Huang, Xiaobin, Rodrigues, Emilie Dooms, Leijten, Jeroen C.H., Verrips, Theo, El Khattabi, Mohamed, Karperien, Marcel, Post, Janine N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Mary Ann Liebert, Inc. 2016
Gaiak:
Original Research Reports
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124737/
https://ncbi.nlm.nih.gov/pubmed/27733096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2016.0222
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