Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Hypertrophic differentiation occurs during in vitro chondrogenesis of mesenchymal stem cells (MSCs), decreasing the quality of the cartilage construct. Previously we identified WNT pathway antagonists Dickkopf 1 homolog (DKK1) and frizzled-related protein (FRZB) as key factors in blocking hypertroph...

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Publicado en:Stem Cells Dev
Autores principales: Zhong, Leilei, Huang, Xiaobin, Rodrigues, Emilie Dooms, Leijten, Jeroen C.H., Verrips, Theo, El Khattabi, Mohamed, Karperien, Marcel, Post, Janine N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Original Research Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124737/
https://ncbi.nlm.nih.gov/pubmed/27733096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2016.0222
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