Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Hypertrophic differentiation occurs during in vitro chondrogenesis of mesenchymal stem cells (MSCs), decreasing the quality of the cartilage construct. Previously we identified WNT pathway antagonists Dickkopf 1 homolog (DKK1) and frizzled-related protein (FRZB) as key factors in blocking hypertroph...

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Detalhes bibliográficos
Publicado no:Stem Cells Dev
Main Authors: Zhong, Leilei, Huang, Xiaobin, Rodrigues, Emilie Dooms, Leijten, Jeroen C.H., Verrips, Theo, El Khattabi, Mohamed, Karperien, Marcel, Post, Janine N.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124737/
https://ncbi.nlm.nih.gov/pubmed/27733096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2016.0222
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