p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis

BACKGROUND: Dominant-negative somatic mutations of p53 has been identified in the synovium of patients with rheumatoid arthritis (RA), in which interleukin (IL)-6 has been established as a pivotal inflammatory cytokine. The aim of this study was to clarify the significance of p53 in the longstanding...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Zhang, Ting, Li, Huihua, Shi, Juan, Li, Sha, Li, Muyuan, Zhang, Lei, Zheng, Leting, Zheng, Dexian, Tang, Fulin, Zhang, Xuan, Zhang, Fengchun, You, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121977/
https://ncbi.nlm.nih.gov/pubmed/27881147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1161-4
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