Increased HIF-1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis

Fibroblast-like synoviocytes (FLSs) are the main effector cells of knee osteoarthritis (KOA) synovial fibrosis. Our last report showed that NLRP1 and NLRP3 inflammasomes may mediate LPS/ATP-induced FLSs pyroptosis in KOA. In the present study, we found an elevated hypoxia-inducible factor-1α (HIF-1α...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Zhang, Li, Huang, Zhengquan, Xing, Runlin, Li, Xiaochen, Yin, Songjiang, Mao, Jun, Zhang, Nongshan, Mei, Wei, Ding, Liang, Wang, Peimin
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348923/
https://ncbi.nlm.nih.gov/pubmed/30755787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/6326517
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