Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice

Cholestasis is a condition that leads to chronic hepatobiliary inflammation, fibrosis, and eventually cirrhosis. Many microRNAs (miRs) are known to play a role in fibrosis progression; however, the role of miR-21 during cholestasis remains unknown. Therefore, the aim of this study was to elucidate t...

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Dettagli Bibliografici
Pubblicato in:Lab Invest
Autori principali: Kennedy, Lindsey, Meng, Fanyin, Venter, Julie, Zhou, Tianhao, Karstens, Walker, Hargrove, Laura, Wu, Nan, Kyritsi, Konstantina, Greene, John, Invernizzi, Pietro, Bernuzzi, Francesca, Glaser, Shannon, Francis, Heather, Alpini, Gianfranco
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121007/
https://ncbi.nlm.nih.gov/pubmed/27775690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2016.112
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