The structure of a doripenem‐bound OXA‐51 class D β‐lactamase variant with enhanced carbapenemase activity

OXA‐51 is a class D β‐lactamase that is thought to be the native carbapenemase of Acinetobacter baumannii. Many variants of OXA‐51 containing active site substitutions have been identified from A. baumannii isolates, and some of these substitutions increase hydrolytic activity toward carbapenem anti...

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Publicado no:Protein Sci
Main Authors: June, Cynthia M., Muckenthaler, Taylor J., Schroder, Emma C., Klamer, Zachary L., Wawrzak, Zdzislaw, Powers, Rachel A., Szarecka, Agnieszka, Leonard, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119573/
https://ncbi.nlm.nih.gov/pubmed/27636561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3040
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