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Structural basis for enhancement of carbapenemase activity in the OXA-51 family of class D β- lactamases

Class D β-lactamases of Acinetobacter baumannii are enzymes of the utmost clinical importance, producing resistance to last resort carbapenem antibiotics. Although the OXA-51-like enzymes constitute the largest family of class D β-lactamases, they are poorly studied and their importance in conferrin...

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Détails bibliographiques
Publié dans:ACS Chem Biol
Auteurs principaux: Smith, Clyde A., Antunes, Nuno Tiago, Stewart, Nichole K., Frase, Hilary, Toth, Marta, Kantardjieff, Katherine A., Vakulenko, Sergei
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546549/
https://ncbi.nlm.nih.gov/pubmed/26042471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00090
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