Clinical Variants of the Native Class D β-Lactamase of Acinetobacter baumannii Pose an Emerging Threat through Increased Hydrolytic Activity against Carbapenems

The threat posed by the chromosomally encoded class D β-lactamase of Acinetobacter baumannii (OXA-51/66) has been unclear, in part because of its relatively low affinity and turnover rate for carbapenems. Several hundred clinical variants of OXA-51/66 have been reported, many with substitutions of a...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Schroder, Emma C., Klamer, Zachary L., Saral, Aysegul, Sugg, Kyle A., June, Cynthia M., Wymore, Troy, Szarecka, Agnieszka, Leonard, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038279/
https://ncbi.nlm.nih.gov/pubmed/27480863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01277-16
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