Hydrolytic Mechanism of OXA-58 Enzyme, a Carbapenem-hydrolyzing Class D β-Lactamase from Acinetobacter baumannii

Carbapenem-hydrolyzing class D β-lactamases (CHDLs) represent an emerging antibiotic resistance mechanism encountered among the most opportunistic Gram-negative bacterial pathogens. We report here the substrate kinetics and mechanistic characterization of a prominent CHDL, the OXA-58 enzyme, from Ac...

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Hauptverfasser: Verma, Vidhu, Testero, Sebastian A., Amini, Kaveh, Wei, William, Liu, Jerome, Balachandran, Naresh, Monoharan, Tharseekan, Stynes, Siobhan, Kotra, Lakshmi P., Golemi-Kotra, Dasantila
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199476/
https://ncbi.nlm.nih.gov/pubmed/21880707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280115
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