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Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum

Plasmodium parasites are responsible for the devastating disease malaria that affects hundreds of millions of people each year. Blood stage parasites establish new permeability pathways (NPPs) in infected red blood cell membranes to facilitate the uptake of nutrients and removal of parasite waste pr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dickerman, Benjamin K., Elsworth, Brendan, Cobbold, Simon A., Nie, Catherine Q., McConville, Malcolm J., Crabb, Brendan S., Gilson, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118696/
https://ncbi.nlm.nih.gov/pubmed/27874068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37502
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