BET inhibitors suppress ALDH activity by targeting ALDH1A1 super-enhancer in ovarian cancer

The emergence of tumor cells with certain stem-like characteristics such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 expression contributes to chemotherapy resistance and tumor relapse. However, clinically applicable inhibitors of ALDH activity have not been reported. There is evid...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Yokoyama, Yuhki, Zhu, Hengrui, Lee, Jeong Heon, Kossenkov, Andrew V., Wu, Sherry Y., Wickramasinghe, Jayamanna M., Yin, Xiangfan, Palozola, Katherine C., Gardini, Alessandro, Showe, Louise C., Zaret, Kenneth S., Liu, Qin, Speicher, David, Conejo-Garcia, Jose R., Bradner, James E., Zhang, Zhiguo, Sood, Anil K., Ordog, Tamas, Bitler, Benjamin G., Zhang, Rugang
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117661/
https://ncbi.nlm.nih.gov/pubmed/27803105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0854
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