The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level

Inactivating mutations in ARID1A, which encodes a subunit of the SWI/SNF chromatin-remodeling complex, are found in over half of ovarian clear cell carcinoma cases and more broadly across most types of cancers. To identify ARID1A-dependent changes in intracellular signaling pathways, we performed pr...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Proteomics
Autori principali: Goldman, Aaron R., Bitler, Benjamin G., Schug, Zachary, Conejo-Garcia, Jose R., Zhang, Rugang, Speicher, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098034/
https://ncbi.nlm.nih.gov/pubmed/27654507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.062539
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