Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations

The components of the Switch/Sucrose non-fermentable (SWI/SNF) complex are mutated in approximately 20% of human cancers. The A/T-rich interacting domain 1A (ARID1A) subunit has one of the highest mutation rates. Most notably, ARID1A is mutated in over 50% of ovarian clear cell carcinomas (OCCCs). W...

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Bibliographic Details
Published in:Mol Cell Oncol
Main Authors: Bitler, Benjamin G, Aird, Katherine M, Zhang, Rugang
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845188/
https://ncbi.nlm.nih.gov/pubmed/27308548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1032476
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