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ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

Both p150 and p110 isoforms of ADAR1 convert adenosine to inosine in double-stranded RNA (dsRNA). ADAR1p150 suppresses the dsRNA sensing mechanism that activates MDA5-MAVS-IFN signaling in the cytoplasm. In contrast, the biological function of the ADAR1p110 isoform, usually located in the nucleus, r...

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Библиографические подробности
Опубликовано в: :Nat Struct Mol Biol
Главные авторы: Sakurai, Masayuki, Shiromoto, Yusuke, Ota, Hiromitsu, Song, Chunzi, Kossenkov, Andrew V., Wickramasinghe, Jayamanna, Showe, Louise C., Skordalakes, Emmanuel, Tang, Hsin-Yao, Speicher, David W., Nishikura, Kazuko
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461201/
https://ncbi.nlm.nih.gov/pubmed/28436945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3403
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