ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

Both p150 and p110 isoforms of ADAR1 convert adenosine to inosine in double-stranded RNA (dsRNA). ADAR1p150 suppresses the dsRNA sensing mechanism that activates MDA5-MAVS-IFN signaling in the cytoplasm. In contrast, the biological function of the ADAR1p110 isoform, usually located in the nucleus, r...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Sakurai, Masayuki, Shiromoto, Yusuke, Ota, Hiromitsu, Song, Chunzi, Kossenkov, Andrew V., Wickramasinghe, Jayamanna, Showe, Louise C., Skordalakes, Emmanuel, Tang, Hsin-Yao, Speicher, David W., Nishikura, Kazuko
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461201/
https://ncbi.nlm.nih.gov/pubmed/28436945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3403
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados