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BET Bromodomain Inhibition Promotes Anti-Tumor Immunity by Suppressing PD-L1 expression
Restoration of anti-tumor immunity by blocking PD-L1 signaling using antibodies has proven to be beneficial in cancer therapy. Here we show that BET bromodomain inhibition suppresses PD-L1 expression and limits tumor progression in ovarian cancer. CD274 (encoding PD-L1) is a direct target of BRD4-me...
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| izdano v: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5177024/ https://ncbi.nlm.nih.gov/pubmed/27626654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.032 |
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