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Members of the Rusc protein family interact with Sufu and inhibit vertebrate Hedgehog signaling
Hedgehog (Hh) signaling is fundamentally important for development and adult tissue homeostasis. It is well established that in vertebrates Sufu directly binds and inhibits Gli proteins, the downstream mediators of Hh signaling. However, it is unclear how the inhibitory function of Sufu towards Gli...
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| Publié dans: | Development |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Company of Biologists Ltd
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5117142/ https://ncbi.nlm.nih.gov/pubmed/27633991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.138917 |
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