Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

Control of Gli function by Suppressor of Fused (Sufu), a major negative regulator, is a key step in mammalian Hedgehog (Hh) signaling, but how this is achieved in the nucleus is unknown. We found that Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Lin, Chuwen, Yao, Erica, Wang, Kevin, Nozawa, Yoko, Shimizu, Hirohito, Johnson, Jeffrey R., Chen, Jau-Nian, Krogan, Nevan J., Chuang, Pao-Tien
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233246/
https://ncbi.nlm.nih.gov/pubmed/25403183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249425.114
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