Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

Control of Gli function by Suppressor of Fused (Sufu), a major negative regulator, is a key step in mammalian Hedgehog (Hh) signaling, but how this is achieved in the nucleus is unknown. We found that Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Dev
Prif Awduron: Lin, Chuwen, Yao, Erica, Wang, Kevin, Nozawa, Yoko, Shimizu, Hirohito, Johnson, Jeffrey R., Chen, Jau-Nian, Krogan, Nevan J., Chuang, Pao-Tien
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2014
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233246/
https://ncbi.nlm.nih.gov/pubmed/25403183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249425.114
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg