Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

Control of Gli function by Suppressor of Fused (Sufu), a major negative regulator, is a key step in mammalian Hedgehog (Hh) signaling, but how this is achieved in the nucleus is unknown. We found that Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the...

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Dades bibliogràfiques
Publicat a:Genes Dev
Autors principals: Lin, Chuwen, Yao, Erica, Wang, Kevin, Nozawa, Yoko, Shimizu, Hirohito, Johnson, Jeffrey R., Chen, Jau-Nian, Krogan, Nevan J., Chuang, Pao-Tien
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233246/
https://ncbi.nlm.nih.gov/pubmed/25403183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249425.114
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