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Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling
Control of Gli function by Suppressor of Fused (Sufu), a major negative regulator, is a key step in mammalian Hedgehog (Hh) signaling, but how this is achieved in the nucleus is unknown. We found that Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the...
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| 出版年: | Genes Dev |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4233246/ https://ncbi.nlm.nih.gov/pubmed/25403183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249425.114 |
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