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Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

Control of Gli function by Suppressor of Fused (Sufu), a major negative regulator, is a key step in mammalian Hedgehog (Hh) signaling, but how this is achieved in the nucleus is unknown. We found that Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the...

詳細記述

保存先:
書誌詳細
出版年:Genes Dev
主要な著者: Lin, Chuwen, Yao, Erica, Wang, Kevin, Nozawa, Yoko, Shimizu, Hirohito, Johnson, Jeffrey R., Chen, Jau-Nian, Krogan, Nevan J., Chuang, Pao-Tien
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233246/
https://ncbi.nlm.nih.gov/pubmed/25403183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249425.114
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