Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

Control of Gli function by Suppressor of Fused (Sufu), a major negative regulator, is a key step in mammalian Hedgehog (Hh) signaling, but how this is achieved in the nucleus is unknown. We found that Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the...

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Bibliografische gegevens
Gepubliceerd in:Genes Dev
Hoofdauteurs: Lin, Chuwen, Yao, Erica, Wang, Kevin, Nozawa, Yoko, Shimizu, Hirohito, Johnson, Jeffrey R., Chen, Jau-Nian, Krogan, Nevan J., Chuang, Pao-Tien
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2014
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233246/
https://ncbi.nlm.nih.gov/pubmed/25403183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249425.114
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