Immunization with outer membrane vesicles displaying designer glycotopes yields class-switched, glycan-specific antibodies

The development of antibodies against specific glycan epitopes poses a significant challenge due to difficulties obtaining desired glycans at sufficient quantity and purity, and the fact that glycans are usually weakly immunogenic. To address this challenge, we leveraged the potent immunostimulatory...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Valentine, Jenny L., Chen, Linxiao, Perregaux, Emily C., Weyant, Kevin B., Rosenthal, Joseph A., Heiss, Christian, Azadi, Parastoo, Fisher, Adam C., Putnam, David, Moe, Gregory R., Merritt, Judith H., DeLisa, Matthew P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116915/
https://ncbi.nlm.nih.gov/pubmed/27341433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.05.014
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