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17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
Asthma and autoimmune disease susceptibility has been strongly linked to genetic variants in the 17q21 haploblock that alter the expression of ORMDL3; however, the molecular mechanisms by which these variants perturb gene expression and the cell types in which this effect is most prominent are uncle...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5116091/ https://ncbi.nlm.nih.gov/pubmed/27848966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13426 |
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