17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

Asthma and autoimmune disease susceptibility has been strongly linked to genetic variants in the 17q21 haploblock that alter the expression of ORMDL3; however, the molecular mechanisms by which these variants perturb gene expression and the cell types in which this effect is most prominent are uncle...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Schmiedel, Benjamin Joachim, Seumois, Grégory, Samaniego-Castruita, Daniela, Cayford, Justin, Schulten, Veronique, Chavez, Lukas, Ay, Ferhat, Sette, Alessandro, Peters, Bjoern, Vijayanand, Pandurangan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116091/
https://ncbi.nlm.nih.gov/pubmed/27848966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13426
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