Liver Serine Palmitoyltransferase (SPT) Activity Deficiency in Early Life Impairs Adherens Junctions and Promotes Tumorigenesis

Serine palmitoyltransferase (SPT) is the key enzyme in sphingolipid biosynthesis. Mice lacking SPT are embryonic lethal. We prepared liver-specific Sptlc2 deficient mice using an albumin-Cre approach, we found that the deficient mice have severe jaundice. Moreover, the deficiency impairs hepatocyte...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Hepatology
Main Authors: Li, Zhiqiang, Kabir, Inamul, Jiang, Hui, Zhou, Hongwen, Libien, Jenny, Zeng, Jianying, Stanek, Albert, Ou, Peiqi, Li, Kailyn R., Zhang, Shane, Bui, Hai H., Kuo, Ming-Shang, Park, Tae-Sik, Kim, Benjamin, Worgall, Tilla S., Huan, Chongmin, Jiang, Xian-Cheng
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115983/
https://ncbi.nlm.nih.gov/pubmed/27642075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28845
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares