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Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function
Serine palmitoyltransferase (SPT) is the rate-limiting enzyme for sphingolipid biosynthesis. SPT has two major subunits, SPTLC1 and SPTLC2. We previously found that liver Sptlc2 deficiency in early life impairs the development of adherens junctions. Here, we investigated the role of Sptlc2 deficienc...
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| Foilsithe in: | Cell Death Dis |
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| Main Authors: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Nature Publishing Group UK
2018
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5833386/ https://ncbi.nlm.nih.gov/pubmed/29415989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0214-1 |
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