Liver Serine Palmitoyltransferase (SPT) Activity Deficiency in Early Life Impairs Adherens Junctions and Promotes Tumorigenesis

Serine palmitoyltransferase (SPT) is the key enzyme in sphingolipid biosynthesis. Mice lacking SPT are embryonic lethal. We prepared liver-specific Sptlc2 deficient mice using an albumin-Cre approach, we found that the deficient mice have severe jaundice. Moreover, the deficiency impairs hepatocyte...

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Published in:Hepatology
Main Authors: Li, Zhiqiang, Kabir, Inamul, Jiang, Hui, Zhou, Hongwen, Libien, Jenny, Zeng, Jianying, Stanek, Albert, Ou, Peiqi, Li, Kailyn R., Zhang, Shane, Bui, Hai H., Kuo, Ming-Shang, Park, Tae-Sik, Kim, Benjamin, Worgall, Tilla S., Huan, Chongmin, Jiang, Xian-Cheng
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115983/
https://ncbi.nlm.nih.gov/pubmed/27642075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28845
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