CFTR controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity

In the liver, CFTR regulates bile secretion and other functions at the apical membrane of biliary epithelial cells (i.e cholangiocytes). CF-related liver disease (CFLD) is a major cause of death in patients with CF. CFTR dysfunction affects innate immune pathways, generating a para-inflammatory stat...

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Veröffentlicht in:Hepatology
Hauptverfasser: Fiorotto, Romina, Villani, Ambra, Kourtidis, Antonis, Scirpo, Roberto, Amenduni, Mariangela, Geibel, Peter J., Cadamuro, Massimilano, Spirli, Carlo, Anastasiadis, Panos Z., Strazzabosco, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115965/
https://ncbi.nlm.nih.gov/pubmed/27629435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28817
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