Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4–NF-κB–Mediated Inflammatory Response in Mice

BACKGROUND & AIMS: Loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) in the biliary epithelium reduces bile flow and alkalinization in patients with CF. Liver damage is thought to result from ductal cholestasis, but only 30% of patients with CF develop liver defe...

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Autores principales: Fiorotto, Romina, Scirpo, Roberto, Trauner, Michael, Fabris, Luca, Hoque, Rafaz, Spirli, Carlo, Strazzabosco, Mario
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186841/
https://ncbi.nlm.nih.gov/pubmed/21712022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.06.052
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