Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4–NF-κB–Mediated Inflammatory Response in Mice

BACKGROUND & AIMS: Loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) in the biliary epithelium reduces bile flow and alkalinization in patients with CF. Liver damage is thought to result from ductal cholestasis, but only 30% of patients with CF develop liver defe...

Full description

Saved in:
Bibliographic Details
Main Authors: Fiorotto, Romina, Scirpo, Roberto, Trauner, Michael, Fabris, Luca, Hoque, Rafaz, Spirli, Carlo, Strazzabosco, Mario
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186841/
https://ncbi.nlm.nih.gov/pubmed/21712022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.06.052
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items