17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway

BACKGROUND: Tumor necrosis factor-α (TNF-α) has been widely known to induce degeneration of nucleus pulposus cells (NPCs). 17β-estradiol (17β-E2) has been broadly proven for its function of suppressing cell apoptosis. The aim of this study is to explore whether 17β-E2 protects apoptosis of human NPC...

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Udgivet i:Med Sci Monit
Main Authors: Wang, Tao, Yang, Si-Dong, Liu, Sen, Wang, Hui, Liu, Huan, Ding, Wen-Yuan
Format: Artigo
Sprog:Inglês
Udgivet: International Scientific Literature, Inc. 2016
Fag:
Lab/In Vitro Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115218/
https://ncbi.nlm.nih.gov/pubmed/27847386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.900310
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