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USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway

OBJECTIVES: Degenerative disc disease is characterized by an enhanced breakdown of its existing nucleus pulposus (NP) matrix due to the dysregulation of matrix enzymes and factors. Ubiquitin‐specific protease 15 (USP15) is reported to be abnormal in certain human diseases. However, its role in NP de...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Yu, Bin, Shen, Bin, Ba, Zhaoyu, Liu, Zhonghan, Yuan, Jing, Zhao, Weidong, Wu, Desheng
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754067/
https://ncbi.nlm.nih.gov/pubmed/33135363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15971
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