USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway

OBJECTIVES: Degenerative disc disease is characterized by an enhanced breakdown of its existing nucleus pulposus (NP) matrix due to the dysregulation of matrix enzymes and factors. Ubiquitin‐specific protease 15 (USP15) is reported to be abnormal in certain human diseases. However, its role in NP de...

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Bibliografske podrobnosti
izdano v:J Cell Mol Med
Main Authors: Yu, Bin, Shen, Bin, Ba, Zhaoyu, Liu, Zhonghan, Yuan, Jing, Zhao, Weidong, Wu, Desheng
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754067/
https://ncbi.nlm.nih.gov/pubmed/33135363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15971
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