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USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway

OBJECTIVES: Degenerative disc disease is characterized by an enhanced breakdown of its existing nucleus pulposus (NP) matrix due to the dysregulation of matrix enzymes and factors. Ubiquitin‐specific protease 15 (USP15) is reported to be abnormal in certain human diseases. However, its role in NP de...

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Dades bibliogràfiques
Publicat a:J Cell Mol Med
Autors principals: Yu, Bin, Shen, Bin, Ba, Zhaoyu, Liu, Zhonghan, Yuan, Jing, Zhao, Weidong, Wu, Desheng
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754067/
https://ncbi.nlm.nih.gov/pubmed/33135363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15971
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