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Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age

With age, somatically derived mitochondrial DNA (mtDNA) deletion mutations arise in many tissues and species. In skeletal muscle, deletion mutations clonally accumulate along the length of individual fibers. At high intrafiber abundances, these mutations disrupt individual cell respiration and are l...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Herbst, Allen, Wanagat, Jonathan, Cheema, Nashwa, Widjaja, Kevin, McKenzie, Debbie, Aiken, Judd M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114866/
https://ncbi.nlm.nih.gov/pubmed/27561813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12520
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