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Accumulation of Mitochondrial DNA Deletion Mutations in Aged Muscle Fibers: Evidence for a Causal Role in Muscle Fiber Loss

Although mitochondrial mutation abundance has been recognized to increase in an age-dependent manner, the impact of mutation has been more difficult to establish. Using quantitative PCR, we measured the intracellular abundance of mutant and wild-type mitochondrial genomes along the length of individ...

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Библиографические подробности
Главные авторы: Herbst, Allen, Pak, Jeong W., McKenzie, Debbie, Bua, Entela, Bassiouni, Marwa, Aiken, Judd M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846622/
https://ncbi.nlm.nih.gov/pubmed/17389720
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