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Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age
With age, somatically derived mitochondrial DNA (mtDNA) deletion mutations arise in many tissues and species. In skeletal muscle, deletion mutations clonally accumulate along the length of individual fibers. At high intrafiber abundances, these mutations disrupt individual cell respiration and are l...
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| Veröffentlicht in: | Aging Cell |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5114866/ https://ncbi.nlm.nih.gov/pubmed/27561813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12520 |
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