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Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age
With age, somatically derived mitochondrial DNA (mtDNA) deletion mutations arise in many tissues and species. In skeletal muscle, deletion mutations clonally accumulate along the length of individual fibers. At high intrafiber abundances, these mutations disrupt individual cell respiration and are l...
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| Publié dans: | Aging Cell |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5114866/ https://ncbi.nlm.nih.gov/pubmed/27561813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12520 |
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